John F. McDonald: The contribution of small regulatory RNAs to cancer metastasis: an evolutionary perspective
The transition of normal healthy cells into malignant cancer cells is an adaptive evolutionary process displaying many of the characteristics long studied and previously described by evolutionary biologists. Conversely, a number of recently discovered molecular processes underlying cancer onset and progression may have general relevance to novel molecular processes underlying evolutionary change as well. In this talk, I will focus on work done in my laboratory on the contribution of small regulatory RNAs to cancer metastasis. Emphasis will be placed on molecular changes that facilitate the metastatic process and their potential relevance to adaptive evolution in general.
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